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CAS No. 202914-84-9 | BMS 201038-04

Name: BMS 201038-04 CAS No.202914-84-9 MF:C40H41F6N3O5S MW:789.8260592 Purity:97% Package: 10g,25g,50g,100g,250g Worldwide Delivery

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Biochemicals

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Product introduction

Introduction and application of CAS No. 202914-84-9 | BMS 201038-04

Synonyms:LoMitapide Mesylate;

BMS 201038 methanesulfonic acid salt;

AEGR 733 Mesylate;

BMS 201038 Mesylate;

Specification:

ITEMS	SPECIFICATION
CAS	202914-84-9
MF	C40H41F6N3O5S
MW	789.8260592
Solubility	DMSO: 100.0 (maximum concentration mg/mL); 126.61 (maximum concentration mM) Ethanol: 100.0 (maximum concentration mg/mL); 126.61 (maximum concentration mM)
Storage condition	Inert atmosphere,Room Temperature

Mechanism of action: Microsomal triglyceride transfer protein (MTP) is located in the microsome lumen of liver cells and small intestinal cells. It was discovered after apolipoprotein B (apoB) and is involved in triglyceride transport and very low-density lipoprotein assembly. Endoplasmic reticulum luminal protein is one of the important lipid transport proteins. This product can directly bind and inhibit MTP, thereby preventing the assembly of apoB-containing lipoproteins in intestinal epithelial cells and hepatocytes, and inhibiting the synthesis of chylomicrons and very low-density lipoproteins. Inhibiting the synthesis of very low-density lipoprotein can reduce plasma low-density lipoprotein.

use:

The drug is approved for use with a low-fat diet and other lipid-lowering drugs to treat homozygous familial hypercholesterolemia (HoFH).

Indications:

Lomitapide is suitable for patients with HoFH as an adjunct to low-fat diet (energy supplied from fat <20%) and other lipid-lowering treatments. It can also be used as an adjunct to LDL blood separation and replacement to reduce LDLC in patients with HoFH. , total cholesterol (TC), apoB and non-HDL cholesterol.

Biological activity:

Lomitapide Mesylate is a potent inhibitor of microsomal triglyceride transfer protein (MTP) used to treat familial hypercholesterolemia.

Package and transportation :

Package: 10g,25g,50g,100g,250g